CORRELATION BETWEEN FELV INFECTION AND FIV AND THE DEVELOPMENT OF HEMATOPOIETIC NEOPLASMS IN FELINES

Authors

  • Richardson Maia Felipe
  • Ana Paula de Moura Nardi
  • Maria Aline Leitão Scatambuli
  • Francisco Ítalo Cassiano Candido
  • Marcos Vinicius Vidal Silva
  • Isabella Silva Borges
  • João Paulo Yoshio Prado Cerqueira Kubota
  • Amanda Ferreira de Jesus
  • Lourdes Maria Bento Campello
  • Livia Mara Guerra Diniz
  • Gabrielly de Lima Silva
  • Elisa Pereira Sarlo
  • Edson Farias
  • Marcos Henrique da Silva
  • Jéssica Caloraine Trelha dos Santos
  • Luana Henriques Costa
  • Natália Araujo de Lima

DOI:

https://doi.org/10.56238/isevmjv4n2-024

Keywords:

Diagnosis, Lymphoma, Leukaemia, Oncogenesis, Retrovirus

Abstract

Objective: To examine the correlation between FeLV (feline leukemia virus) and FIV (feline immunodeficiency virus) retrovirus infections and the development of hematopoietic neoplasms in felines, focusing on the clinical and prognostic implications of these infections. Hematopoietic neoplasms, especially lymphomas and leukemias, are frequent in felines, with retroviruses playing critical roles in oncogenesis. FeLV has direct oncogenic action, while IVF promotes oncogenesis by immunosuppression. This study was conducted through a narrative review of the literature, including scientific articles, monographs, and case reports. The results revealed that FeLV-positive cats have a higher risk of multicentric lymphomas, while those infected by FIV have a higher predisposition to foodborne lymphomas. Co-infection with both retroviruses significantly increases the risk of developing lymphomas and leukemias. Modern diagnostic approaches such as PCR-PARR and flow cytometry are essential for staging and targeted treatment. Treatment with chemotherapy protocols, such as COP and CHOP, offers temporary control, but survival rates remain low. It is concluded that it is essential to implement prevention and serological testing programs to reduce the prevalence of retroviruses and associated neoplasms.

Published

2025-04-28

How to Cite

CORRELATION BETWEEN FELV INFECTION AND FIV AND THE DEVELOPMENT OF HEMATOPOIETIC NEOPLASMS IN FELINES. (2025). International Seven Journal of Multidisciplinary, 4(2), 409-418. https://doi.org/10.56238/isevmjv4n2-024