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Analysis of the benefits of developing vaccines against leishmaniasis compared to the classic treatment

  • 640-655
  • 14/08/2024
  • 14/08/2024
da Silva LRS;
da Silva LRS;
Costa YKS;
da Rocha FHBP;
de Sousa VFA;
Pereira LM;
Fais JP;
Araújo JVB;
de Andrade SNB;
Siriano TP

Lucas Rocha Santana da Silva

Luiza Rocha Santana da Silva

Yane Keli dos Santos Costa

Fabiane Holanda Batista Porfírio da Rocha

Vitória Faustino Araujo de Sousa

Lívia Messias Pereira

João Pedro Fais

João Victor Barros Araújo

Suzane Nunes Barreto de Andrade

Tiago Pinto Siriano

Keywords

Leishmaniasis
Drug Treatment
Vaccine
Prophylaxis

Abstract

Introduction: The treatment of leishmaniasis in humans faces challenges such as drug resistance and treatment abandonment. In this context, the search for an effective vaccine is crucial as a prophylactic measure. This study compares drug treatment and vaccination.

Methodology: An integrative review was carried out with the descriptors "leishmaniasis", "treatment", "vaccine" and "prevention" in databases such as PUBMED, Scielo, Medscape and DATASUS Tabnet.Results: Drug treatment includes three lines of medications, each with distinct challenges. On the other hand, vaccination is seen as a primary measure of immunoprophylaxis, with different generations of vaccines, including those based on the parasite's DNA. Discussion: In developing countries, such as Brazil, the need for effective and accessible treatment is pressing. Vaccination has advantages in cost and effectiveness, but more studies are needed to consolidate this form of prevention. Final Considerations: Investing in vaccines against leishmaniasis offers advantages in cost and effectiveness compared to drug treatment. Given the failures of conventional treatment, vaccination emerges as a promising prevention strategy.

 

DOI:https://doi.org/10.56238/sevened2024.018-043

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2024 Lucas Rocha Santana da Silva , D.C.B. Bezerra, Luiza Rocha Santana da Silva , Yane Keli dos Santos Costa , Fabiane Holanda Batista Porfírio da Rocha , L.L.S Lima, F.P.B Silva, A.D Chiacchio, Vitória Faustino Araujo de Sousa, Lívia Messias Pereira, João Pedro Fais, João Victor Barros Araújo, Suzane Nunes Barreto de Andrade
Chapter 43
Versão (Português (Brasil))

Author(s)

  • Lucas Rocha Santana da Silva
  • Luiza Rocha Santana da Silva
  • Yane Keli dos Santos Costa
  • Fabiane Holanda Batista Porfírio da Rocha
  • Vitória Faustino Araujo de Sousa
  • Lívia Messias Pereira
  • João Pedro Fais
  • João Victor Barros Araújo
  • Suzane Nunes Barreto de Andrade
  • Tiago Pinto Siriano