Impact of obesity on Gleason Score in elderly and elderly patients with Prostate Cancer with indication for radical radiotherapy
DOI:
https://doi.org/10.56238/rcsv14n3-014Keywords:
Prostate Neoplasms, Body Mass Index, RadiotherapyAbstract
Prostate cancer is an important public health concern in Brazil, especially among elderly men, with a significant mortality rate. In addition to advanced age, obesity emerges as a relevant risk factor, associated with a worse prognosis of the disease. Objective: To investigate the relationship between body mass index (BMI) and Gleason score in elderly and elderly patients with prostate cancer indicated for radiotherapy. Methodology: Prospective, descriptive and longitudinal study with 35 patients with prostate cancer, evaluating age, initial PSA, BMI, race and Gleason score. Results: The findings revealed an association between a higher BMI and a more aggressive degree of the disease, as indicated by higher Gleason scores. Conclusion: Overweight and obese patients have a higher and more evident Gleason score in elderly patients compared to the elderly, being more notable in the elderly. This study is one of the few studies to examine the link between BMI and a poor prognosis in patients with prostate cancer.
References
ARCHER, Maddison; DOGRA, Navneet; KYPRIANOU, Natasha. Inflammation as a driver of prostate cancer metastasis and therapeutic resistance. Cancers, v. 12, n. 10, p. 2984, 2020. doi: 10.3390/cancers12102984. PMID: 33076397; PMCID: PMC7602551.
CAO, Yin; GIOVANNUCCI, Edward. Obesity and prostate cancer. Obesity and cancer, p. 137-153, 2016. doi: 10.1007/978-3-319-42542-9_8. PMID: 27909906.
CEDEÑO YERA, Yosbani; FONSECA GONZALEZ, Ramón Luis; CEDENO YERA, Ernesto David. Impacto de la obesidad en la agresividad del cáncer de próstata. Multimed, Granma , v. 25, n. 3, e2317, jun. 2021 . .
GOLEMIS, Erica A. et al. Molecular mechanisms of the preventable causes of cancer in the United States. Genes & development, v. 32, n. 13-14, p. 868-902, 2018. doi: 10.1101/gad.314849.118. Epub 2018 Jun 26. PMID: 29945886; PMCID: PMC6075032.
GONTIJO GOMES, Cássia Regina; RESENDE IZIDORO, Lívia Cristina; FERREIRA DA MATA, Luciana Regina. Fatores de risco para o câncer de próstata e aspectos motivadores e dificultadores na realização das práticas preventivas. Invest. educ. enferm, Medellín , v. 33, n. 3, p. 415-423, Dec. 2015 . . https://doi.org/10.17533/udea.iee.v33n3a04.
IARC Working Group on the Evaluation of Cancer-Preventive Interventions. Absence of excess body fatness. Lyon (FR): International Agency for Research on Cancer; 2021. PMID: 37200467.
Instituto Nacional do Câncer José Alencar Gomes da Silva. Estimativa 2020: Incidência de câncer no Brasil. Rio de Janeiro: INCA,2019. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf
ISHII, Kenichiro et al. Interleukin‐6 induces VEGF secretion from prostate cancer cells in a manner independent of androgen receptor activation. The Prostate, v. 78, n. 11, p. 849-856, 2018. doi: 10.1002/pros.23643. Epub 2018 Apr 29. PMID: 29707793.
KRÜGER, F. P. G.; CAVALCANTI, G. Conhecimento e Atitudes sobre o Câncer de Próstata no Brasil: Revisão Integrativa. Revista Brasileira de Cancerologia, [S. l.], v. 64, n. 4, p. 561–567, 2018. DOI: 10.32635/2176-9745.RBC.2018v64n4.206.
MORI, Rafael Ribeiro et al. Prostate cancer screening among elderly men in Brazil: should we diagnose or not?. International braz j urol, v. 46, p. 34-41, 2019. doi: 10.1590/S1677-5538.IBJU.2019.0022. PMID: 31851456; PMCID: PMC6968892.
PATI, Sukanya et al. Obesity and cancer: A current overview of epidemiology, pathogenesis, outcomes, and management. Cancers, v. 15, n. 2, p. 485, 2023. doi: 10.3390/cancers15020485. PMID: 36672434; PMCID: PMC9857053.
SUNG, Hyuna et al. Global patterns in excess body weight and the associated cancer burden. CA: a cancer journal for clinicians, v. 69, n. 2, p. 88-112, 2019. doi: 10.3322/caac.21499. Epub 2018 Dec 12. PMID: 30548482.
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