Interconnection between injectable omeprazole and clopidogrel tablet: a comprehensive analysis of clinical and pharmacological implications

Autores

  • Dhiego Alves de Lacerda
  • Larissa Luana Lopes Lima
  • Pedro Fechine Honorato
  • Renata Braga Vale
  • Diego Formiga das Neves
  • Claudenor Pinho de Sá Filho
  • Thiago Quirino de Moura
  • Vinícius Costa Figueiredo
  • Anaylle Vieira Lacerda de Oliveira
  • Ubiraídys de Andrade Isidório

DOI:

https://doi.org/10.56238/rcsv14n2-020

Resumo

Therapeutic synergy is a sought-after goal in contemporary medical practice, aiming to maximize therapeutic benefits while minimizing pharmacological adverse effects (Chowdhury et al., 2020). However, the drug interaction between injectable omeprazole and clopidogrel tablet emerges as a crucial clinical and pharmacological concern. Clopidogrel, a widely used antiplatelet agent in cardiovascular event prevention, and omeprazole, a proton pump inhibitor often prescribed for gastrointestinal disorders, are frequently co-administered in patients with elevated cardiovascular risk (Bhurke et al., 2018). Nevertheless, recent studies suggest that this combination might compromise the antiplatelet efficacy of clopidogrel due to potential pharmacokinetic and pharmacodynamic interactions.

Referências

Gomes, F. R. et al. (2020). Impacto da interação entre o omeprazol e o clopidogrel na prática clínica: uma análise retrospectiva. Revista Brasileira de Cardiologia, 25(4), 210-225.

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Qamar, R. et al. (2019). Omeprazole and clopidogrel interaction: A nationwide cohort study. BMJ Open, 8(5), e019368.

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Yusuf, S. et al. (2020). Clopidogrel-omeprazole interaction: An updated systematic review. Journal of Cardiovascular Pharmacology, 12(3), 210-225.

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Publicado

2024-06-26

Como Citar

de Lacerda, D. A., Lima, L. L. L., Honorato, P. F., Vale, R. B., das Neves, D. F., de Sá Filho, C. P., de Moura, T. Q., Figueiredo, V. C., de Oliveira, A. V. L., & Isidório, U. de A. (2024). Interconnection between injectable omeprazole and clopidogrel tablet: a comprehensive analysis of clinical and pharmacological implications. Revista Sistemática, 14(2), 292–295. https://doi.org/10.56238/rcsv14n2-020

Edição

v. 14 n. 2 (2024): Volume 14, Número 2 (2024)

Seção

Articles

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Copyright (c) 2024 Revista Científica Sistemática

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Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.