Profile of angiotensin-converting enzyme activity on nitric oxide levels in type 2 diabetes mellitus patients

Resumo

Nitric oxide and renin angiotensin system are involved in the pathophysiology and progression of diabetes mellitus chronic complications. To evaluate angiotensin-converting enzyme activity on nitric oxide levels in patients with type 2 diabetes mellitus. Were recruited 20 patients and 20 health volunteers. Blood and urine samples were collected to measure: fasting blood glucose, glycated hemoglobin, plasmatic Na+, K+, urea, creatinine, total cholesterol, triglycerides, thiobarbituric acid reactive substances, nitric oxide levels, angiotensin-converting enzyme activity and microalbuminuria.The mean arterial pressure and body mass index were obtained from the medical records. The results were considered significant when p<0.05. Fasting blood glucose, glycated hemoglobin, body mass index, nitric oxide, urinary thiobarbituric acid reactive substances, angiotensin-converting enzyme activity and microalbuminuria were increased and total cholesterol was reduced in diabetic vs. controls; meanwhile MAP, Na+, triglycerides, urea and creatinine were similar between these two groups. Our study showed that although the angiotensin-converting enzyme was elevated, favored by the high oxidative stress level, demonstrating that there was protection on the cardio-renal axis. Our data suggest that maybe angiotensin-converting enzyme inhibitors acted on AT2, demonstrated by increased nitric oxide and stable blood pressure, revealing how dynamic the renin angiotensin system is and reacts to treatment.

DOI:https://doi.org/10.56238/uniknowindevolp-151