Profile of angiotensin-converting enzyme activity on nitric oxide levels in type 2 diabetes mellitus patients
Abstract
Nitric oxide and renin angiotensin system are involved in the pathophysiology and progression of diabetes mellitus chronic complications. To evaluate angiotensin-converting enzyme activity on nitric oxide levels in patients with type 2 diabetes mellitus. Were recruited 20 patients and 20 health volunteers. Blood and urine samples were collected to measure: fasting blood glucose, glycated hemoglobin, plasmatic Na+, K+, urea, creatinine, total cholesterol, triglycerides, thiobarbituric acid reactive substances, nitric oxide levels, angiotensin-converting enzyme activity and microalbuminuria.The mean arterial pressure and body mass index were obtained from the medical records. The results were considered significant when p<0.05. Fasting blood glucose, glycated hemoglobin, body mass index, nitric oxide, urinary thiobarbituric acid reactive substances, angiotensin-converting enzyme activity and microalbuminuria were increased and total cholesterol was reduced in diabetic vs. controls; meanwhile MAP, Na+, triglycerides, urea and creatinine were similar between these two groups. Our study showed that although the angiotensin-converting enzyme was elevated, favored by the high oxidative stress level, demonstrating that there was protection on the cardio-renal axis. Our data suggest that maybe angiotensin-converting enzyme inhibitors acted on AT2, demonstrated by increased nitric oxide and stable blood pressure, revealing how dynamic the renin angiotensin system is and reacts to treatment.
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Copyright (c) 2023 Margaret Gori Mouro, Ana Beatriz Galhardi Di Tommaso, Giovana Rita Punaro, Deyse Yorgos de Lima, Marcos Antonio do Nascimento, Fernanda Aparecida Ronchi, Adelson Marçal Rodrigues, Dulce Elena Casarini, Sergio Atala Dib, Elisa Mieko Suemitsu HigaAuthor(s)
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Margaret Gori Mouro
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Ana Beatriz Galhardi Di Tommaso
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Giovana Rita Punaro
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Deyse Yorgos de Lima
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Marcos Antonio do Nascimento
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Fernanda Aparecida Ronchi
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Adelson Marçal Rodrigues
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Dulce Elena Casarini
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Sergio Atala Dib
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Elisa Mieko Suemitsu Higa