CHANGES IN HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN PATIENTS DUE TO LONG-TERM USE OF OMEPRAZOLE

Abstract

Introduction: Omeprazole (OMZ) is the most frequently used PPI in conditions of Gastroesophageal Reflux Disease (GERD), gastric/duodenal ulcer, erosive esophagitis, H. pylori infection, in addition to being prescribed as a gastric protector in case of use of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) (Sambugaro et al., 2021). Drugs of this class are often well tolerated, their adverse effects are usually manifested with the prolonged use of PPIs (Haastrup et al., 2018). Biochemical alterations may occur, such as hypocalcemia, hypokalemia, hypomagnesemia (Isse; Hashimoto, 2020). Methodology: For the construction of the present research, a systematic review of the qualitative literature was carried out. In this review study, in the search phase, the search was carried out in journal articles, books and dissertations. Results and discussion: According to the study carried out, the prolonged use of omeprazole can generate a series of complications, among them we can mention the decrease in the absorption of vitamin B12, important for hormonal development and for the formation of red blood cells (red blood cells), and iron deficiency, as its use affects the intestinal absorption capacity of micro-elementary nutrients. In addition to affecting the absorption of vitamins and minerals, prolonged use of omeprazole can cause hematological changes such as MCV (Mean Corpuscular Volume), HCM (Mean Corpuscular Hemoglobin) and MCHC (Mean Corpuscular Hemoglobin Concentration). Conclusion: Taking into account the preference for the use of omeprazole as a proton pump inhibitor in the treatment of acid-peptic disorders, attention should be paid to the harm caused by the prolonged use of this drug.

DOI:https://doi.org/10.56238/sevened2024.028-014