Basic principles in antibiotic therapy
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Abstract
In 1877, Louis Pasteur studied the phenomenon of antibiosis, that is, the disharmonious interspecific relationship; however, only years later, the first antibiotic substance was developed, in 1929, by Alexander Fleming, which consisted of a yeast-like colony that reproduced in the vicinity of a petri tree. The antimicrobial spectrum can express the range of action of the drug, that is, it expresses the percentage of bacterial groups sensitive to the drug. The resistance of microorganisms represents a phenomenon of their evolutionary adaptation, which can be natural or acquired. The increase in the number of resistant bacteria may be linked to the mechanism of "induced selection", i.e., antibiotics lyse sensitive organisms, leaving resistant ones unharmed; or through dissemination, which happens through ingestion and/or contact with foods composed of antimicrobials.
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Copyright (c) 2024 Felício de Freitas Netto, André Saad Cleto, Fabiana Postiglione Mansani, Tatiana Menezes Garcia Cordeiro, Jorge Antonio Matkovsky, Polyana Yasmin Hanke, Jessica Mainardes, Rusllan Ribeiro de Paiva Ferreira, Bruno Antunes Brogiatto, Isabela Hess JustusAuthor(s)
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Felício de Freitas Netto
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André Saad Cleto
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Fabiana Postiglione Mansani
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Tatiana Menezes Garcia Cordeiro
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Jorge Antonio Matkovsky
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Polyana Yasmin Hanke
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Jessica Mainardes
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Rusllan Ribeiro de Paiva Ferreira
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Bruno Antunes Brogiatto
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Isabela Hess Justus