CHROMATIN AND IMMUNITY: THE ROLE OF INTRACELLULAR PATHOGENS IN MODULATING IMMUNE CELLS
Keywords:
Modificações epigenéticas, Patógenos intracelulares obrigatórios, Remodelação da cromatina, Resposta imune adaptativaAbstract
This chapter addresses the molecular mechanisms of chromatin remodeling and epigenetic modifications induced by obligate intracellular pathogens, focusing on their effects on the morphology, functionality, and adaptive immune response of lymphocytes. It explores how these pathogens modulate the activation, survival, and function of immune cells, subverting physiological processes to ensure their persistence within the host. The chapter discusses chromatin structure, key epigenetic modifications regulating gene expression, and the temporal dynamics of these changes during infection. Emerging technologies such as ATAC-seq, ChIP-seq, and single-cell sequencing are highlighted for their ability to provide detailed analysis of these processes. Additionally, the interplay between cellular metabolism and epigenetics in immune modulation, as well as the impact of host genetic variability on clinical response heterogeneity, are emphasized. Finally, veterinary pathogens including Rickettsia, Anaplasma, and Ehrlichia are presented as examples illustrating sophisticated epigenetic subversion strategies. Integrating knowledge of these mechanisms lays the groundwork for developing innovative, personalized therapeutic approaches to combat infections by obligate intracellular pathogens.
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Copyright (c) 2025 Marcela Aldrovani Rodrigues, Caio Rafael Siqueira Vasconcelos, Maysa Barbosa de Almeida, Jhuan Luiz Silva, Caroline Pedroso de Oliveira, Fernanda Gosuen Gonçalves Dias
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
