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Hyperglycemic emergencies - epidemiological, physiopathological aspects and therapeutic management

Mittelmann L;
De Araújo Gomes M;
Araujo Gontijo JV;
Ebner Salvato B;
Girão Butruce Santoro J;
Teixeira Izidorio F;
Mariana Cachola Pereira J;
Miranda Espírito Santo E Silva M;
Carvalho Chaves J

Larissa Mittelmann

Mariana De Araújo Gomes

Joao Vitor Araujo Gontijo

Bruna Ebner Salvato

Julia Girão Butruce Santoro

Frederico Teixeira Izidorio

Julia Mariana Cachola Pereira

Mariana Miranda Espírito Santo E Silva

Jênifer Carvalho Chaves


Keywords

acute complications
diabetic ketoacidosis
diabetes mellitus
hyperosmolar hyperglycemic state
metabolic disorders

Abstract

Diabetes mellitus (DM) corresponds  to  a metabolic  immunity  in which  there  is  a definition  of  resistance1, corresponding  to  peripheral  resistance  to  DM, respectively. The disease  has  a high prevalence  and  can  lead to  acute  and  numerous  complications  worldwide, as well  as chronic; in this  sense, diabetic  ketoacidosis  (DKA) and  the  hyperosmolar  hyperglycemic  state  (HHE) correspond  to  the  main  acute  complications  of  the  disease;  diagnosis  and  immediate  treatment  due  to  the  severity  of  the  same  condition  by  them. In addition, both  complications  are called  hyperglycemic  emergencies, precisely  because  of  their  signs  and  symptoms, high blood  glucose can  occur  in a diabetic  patient.  Furthermore, there  are several  causes of  CAD and  EHH;  however, the  main  causes established  in the  literature  are the  presence  of  infections  and  the  inappropriate  use of  insulin  in patients  with  DM. In addition, proper  patient  management in these  circumstances  involves  early  administration  of  intravenous  fluids, insulin  therapy, electrolyte  replacement, and  recognition  and  treatment  of  precipitating  causes.  However, despite  the  existence  of  numerous  protocols  involved  in the  diagnosis  and  treatment  of  DKA and  HHE, little  has  been  done  to  prevent  these   complications; thus, there  is  an  urgent  need  to  better  clarify  diabetic  patients  about  their  disease  and  its likely  complications, as well  as alert  them  to   possible  warning  signs, so  that  they  can  seek  assistance  as early  as possible, reducing  the  likelihood  of  negative outcomes.

 

DOI: https://doi.org/10.56238/tfisdwv1-044


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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2023 Larissa Mittelmann, Mariana De Araújo Gomes, Joao Vitor Araujo Gontijo, Bruna Ebner Salvato , Julia Girão Butruce Santoro, Frederico Teixeira Izidorio, Julia Mariana Cachola Pereira, Mariana Miranda Espírito Santo E Silva, Jênifer Carvalho Chaves

Author(s)

  • Larissa Mittelmann
  • Mariana De Araújo Gomes
  • Joao Vitor Araujo Gontijo
  • Bruna Ebner Salvato
  • Julia Girão Butruce Santoro
  • Frederico Teixeira Izidorio
  • Julia Mariana Cachola Pereira
  • Mariana Miranda Espírito Santo E Silva
  • Jênifer Carvalho Chaves