Association between polymorphisms in the gene encoding the vitamin D receptor, lipid profile and anthropometric parameters in elderly Brazilians
Abstract
Polymorphisms in the vitamin D receptor gene are associated with the severities of several diseases, including overweight and cardiovascular disease. In addition, vitamin D is an important determinant of health and has several functions in bone homeostasis and in various physiological and metabolic mechanisms. From this perspective, this study aimed to evaluate whether there is an association between the genetic variants Fok1 (rs2228570) and Bsm1 (rs1544410) with circulating metabolic markers of the lipid profile and anthropometric measurements in the elderly. This is a cross-sectional study conducted with 173 elderly people from Teresina, Piauí State, Brazil, whose sociodemographic and health characterization occurred through interviews. 25-hydroxyvitamin D [25(OH)D] was measured by chemiluminescence. The cut-off values used as a reference for serum lipids were from the Update of the Brazilian Guideline on Dyslipidemias and Prevention of Atherosclerosis. Genotyping was performed using the restriction fragment length polymorphism technique. The results showed that there were no statistically significant differences between the association of VDR FokI and BsmI gene polymorphisms with BMI, blood pressure and vitamin D concentrations. However, elderly carriers of the BsmI genotype, specifically Bb heterozygotes, were associated with lower values of triglycerides and HDL-cholesterol.
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Copyright (c) 2024 Ivone Freires de Oliveira Costa Nunes, Cecilia Maria Resende Gonçalves de Carvalho, Gabriella Magalhães Silva, Gleyson Moura dos Santos, Maria Eduarda Raielly da Silva, Elane Natielly da Conceição Silva, Nauale Lopes de Araújo, Lynda Sthefanny Alves dos Santos, Laura Beatriz Guimarães Sousa, Gleicer Vívian da Silva Lodoro, Ruth Hellen do Nascimento Gomes, Sarah Celeste Rodrigues de Sousa ValAuthor(s)
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Ivone Freires de Oliveira Costa Nunes
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Cecilia Maria Resende Gonçalves de Carvalho
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Gabriella Magalhães Silva
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Gleyson Moura dos Santos
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Maria Eduarda Raielly da Silva
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Elane Natielly da Conceição Silva
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Nauale Lopes de Araújo
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Lynda Sthefanny Alves dos Santos
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Laura Beatriz Guimarães Sousa
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Gleicer Vívian da Silva Lodoro
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Ruth Hellen do Nascimento Gomes
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Sarah Celeste Rodrigues de Sousa Val