Type 2 diabetes mellitus and Alzheimer's disease in the elderly population: A narrative review
Abstract
Type 2 diabetes has pathological mechanisms similar to those of Alzheimer's, indicating a correlation between the two conditions. This article aims to present the effects of type 2 diabetes mellitus on the development of Alzheimer's, emphasizing the molecular mechanisms that correlate these two factors. This study is a qualitative narrative review that aims to comprehensively present the topic "type 2 diabetes mellitus and Alzheimer's disease in the elderly population". The search was carried out in the virtual libraries PubMed, VHL and Scielo, using keywords and MeSH terms such as "Type 2 Diabetes", "Alzheimer's Disease" and "Susceptibility to Diseases". The search resulted in 252 articles. After several stages of analysis and selection, 8 relevant articles were chosen to compose the narrative review. The review addresses the relationship between Alzheimer's and type 2 diabetes, exploring risk factors, common molecular mechanisms, and the role of glucose in neural function. The review indicates a link between type 2 diabetes and Alzheimer's in the elderly population, with complex biological mechanisms connecting the two conditions. Future research is encouraged to improve patient care.
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Copyright (c) 2024 Larissa Silva Clementino, Ana Georgia Amaro Alencar Bezerra Matos, Rian Barreto Arrais Rodrigues de Morais, Leonardo Torres Camurça, Patricia Cibelle Leite de Morais, Guillermo Cândido de Lorena, Priscila Herbelle Leite de Morais, Wendryus William de Lima, Lucas Casarotto Versa, Douglas Vicente Balensiefer, Genilson Pereira Gurgel, Lara Beatriz Cunha da Silva PaixãoAuthor(s)
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Larissa Silva Clementino
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Ana Georgia Amaro Alencar Bezerra Matos
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Rian Barreto Arrais Rodrigues de Morais
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Leonardo Torres Camurça
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Patricia Cibelle Leite de Morais
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Guillermo Cândido de Lorena
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Priscila Herbelle Leite de Morais
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Wendryus William de Lima
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Lucas Casarotto Versa
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Douglas Vicente Balensiefer
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Genilson Pereira Gurgel
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Lara Beatriz Cunha da Silva Paixão