Animal model of osteochondral injury in rabbits
Abstract
Object: To study the alterations in an osteocondral surface, submitted to a standardized mechanical lesion. Methods: 30 young male rabbits were used for this experiment, being the experimental procedure performed on 60 knees. After anesthesia and antisepsis, the animals were submitted to surgical procedure for osteocondral lesion production with 4,2 X 5,0 millimeters (mm) in their condilus femoralis medialis with standardized instrumental. Three weeks after these animals were evaluated, concerning the lesion. Results: The tissue regeneration was incompatible with spontaneous resolution, developing cicatricial tissue different from the normal cartilage. Conclusions: The developed model animal is useful for study regeneration of the cartilage after mechanical lesion. The model is simple and easy to control and execute, as well as preserves the animals, which may used in other experiments, or for later observations of the previously described and analyzed phenomena in this first report.
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Copyright (c) 2023 Marco Antonio Schueda, Moisés Cohen, Marcelo Salvador Filardi, Danielle do Rocio Brostulin, Carlos José SerapiãoAuthor(s)
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Marco Antonio Schueda
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Moisés Cohen
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Marcelo Salvador Filardi
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Danielle do Rocio Brostulin
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Carlos José Serapião