The leptin receptor gene, its action mechanism, polymorphisms and obesogenic clinical associations

Abstract

With the significant increase in obesity cases worldwide, there is also an increase in research to understand its causes. Known that the predisposing factors may be environmental and / or genetic, the study focused on the Leptin Receptor (LEPR) gene, its action on satiety and the pathophysiology when the presence of polymorphisms, as well as their interaction with comorbidities that are directly related to obesity and increased adipose tissue. In addition, the motivators that influence a greater or lesser production and action of leptin, its pathway through the central nervous system and how this mechanism sends information on the body's lipid stock, thus regulating the body's energy metabolism, were highlighted. The main result of the LEPR gene mutation is leptin resistance, which consequently leads the individual to not have an adequate perception of satiety and body fat stores, the main effect of which is hyperphagia.

DOI:https://doi.org/10.56238/globalhealthprespesc-012