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NFkB1 gene polymorphism increases the risk for occurrence of fatigue and sleep disorder in patients with sporadic PD

Duarte EBC;
Santos EUD;
Cândido SA;
Lima GDC;
Asano AGC;
Asano NMJ;
Maia MMD;
Souza PRE

Elaine Bandeira Cavalcanti Duarte

Erinaldo Ubirajara Damasceno dos Santos

Samantha Amorim Cândido

Géssica Dayane Cordeiro de Lima

Amdore Guescel C. Asano

Nadja Maria Jorge Asano

Maria de Mascena Diniz Maia

Paulo Roberto Eleutério de Souza


Resumo

Objectives The objective of this study was to investigate a possible relationship between genetic variants in the TNFα and NFKB1 genes with the occurrence of fatigue and sleep disorder in patients with Parkinson’s disease (PD).

Methods A total of 180 Brazilian patients from the Pro-Parkinson service at the Clinical Hospital of the Federal University of Pernambuco, diagnosed with sporadic PD were enrolled. The sequence variants for TNFα and NFKB1 were determined through the PCR-RFLP technique. Logistic regression was performed to assess the association of polymorphisms with the occurrence of fatigue and sleep disorder in PD patients.

Key findings Multivariate analysis revealed increased risk for the occurrence of fatigue in individuals carrying NFKB D/W genotype (Prevalence Ratio: PR=2.091; 95%CI, 1.155-3.784; p=0.015) and D/D genotype (PR= 2.237; 95%CI, 1.078-4.643; p=0.031). In addition, it was observed an increased risk to the occurrence of fatigue in PD patients with sleep disorder (PR= 5.226; 95%CI, 2.934-9.307; p= 0.000). Moreover, the therapy with pramipexole was significantly associated with the development of sleep disorder (p = 0.020).

Conclusion NFKB1 variants and use of the pramipexole may have a significant influence on increased risk for the occurrence of fatigue and sleep disorder, respectively in a Brazilian PD population.

 

DOI:https://doi.org/10.56238/ciênciasaudeestuepesv1-086


Creative Commons License

Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2023 Elaine Bandeira Cavalcanti Duarte, Erinaldo Ubirajara Damasceno dos Santos, Samantha Amorim Cândido, Géssica Dayane Cordeiro de Lima, Amdore Guescel C. Asano, Nadja Maria Jorge Asano, Maria de Mascena Diniz Maia, Paulo Roberto Eleutério de Souza

##plugins.themes.gdThemes.article.Authors##

  • Elaine Bandeira Cavalcanti Duarte
  • Erinaldo Ubirajara Damasceno dos Santos
  • Samantha Amorim Cândido
  • Géssica Dayane Cordeiro de Lima
  • Amdore Guescel C. Asano
  • Nadja Maria Jorge Asano
  • Maria de Mascena Diniz Maia
  • Paulo Roberto Eleutério de Souza