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Animal model of osteochondral injury in rabbits

Schueda MA;
Cohen M;
Filardi MS;
Brostulin DR;
Serapião CJ

Marco Antonio Schueda

Moisés Cohen

Marcelo Salvador Filardi

Danielle do Rocio Brostulin

Carlos José Serapião


Resumen

Object: To study the alterations in an osteocondral surface, submitted to a standardized mechanical lesion. Methods: 30 young male rabbits were used for this experiment, being the experimental procedure performed on 60 knees. After anesthesia and antisepsis, the animals were submitted to surgical procedure for osteocondral lesion production with 4,2 X 5,0 millimeters (mm) in their condilus femoralis medialis with standardized instrumental. Three weeks after these animals were evaluated, concerning the lesion. Results: The tissue regeneration was incompatible with spontaneous resolution, developing cicatricial tissue different from the normal cartilage. Conclusions: The developed model animal is useful for study regeneration of the cartilage after mechanical lesion. The model is simple and easy to control and execute, as well as preserves the animals, which may used in other experiments, or for later observations of the previously described and analyzed phenomena in this first report.

 

DOI:https://doi.org/10.56238/uniknowindevolp-109


Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Derechos de autor 2023 Marco Antonio Schueda, Moisés Cohen, Marcelo Salvador Filardi, Danielle do Rocio Brostulin, Carlos José Serapião

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  • Marco Antonio Schueda
  • Moisés Cohen
  • Marcelo Salvador Filardi
  • Danielle do Rocio Brostulin
  • Carlos José Serapião