BRAIN ORGANOIDS: HISTORY, MORPHOFUNCTIONAL ASPECTS AND APPLICATION PERSPECTIVES
Abstract
One of the main goals of neurobiology is to understand the development and dysfunction of the human brain. Many of the tools and techniques that have informed our understanding of human brain development cannot fully capture the unique and dynamic features of human brain development. Recent advances in stem cell technologies that allow the generation of human brain organoids from pluripotent stem cells (PSCs) promise to profoundly change our understanding of human brain development and enable a detailed study of the pathogenesis of hereditary and acquired brain diseases. In this review, we will overview the development of brain organoid technology, its current progress and applications, and future prospects of this technology.
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Copyright (c) 2024 Igor Carreiro Ramalho, Carlos Magno da Costa Maranduba, Fernando de Sá Silva