Cannabis: Past, present, and future

Abstract

Introduction: This work is aimed at understanding the endocannabinoid system and its derivatives, showing in a timeline where we find ourselves in relation to a controversial and marginalized subject. Methodology: The text presents a narrative review of the literature, supported by studies from the PubMed and SciELO platforms. Results and Discussion: In the face of chronic inflammatory processes, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) have been shown to be a therapeutic option in the control of nociception in some diseases, with the potential to relieve pain through activated CB1 and CB2 cannabinoid receptors, which in turn modulate responses to nociceptive stimuli, in particular, induce peripheral tissue repair. Conclusion: With more than 4,500 years of therapeutic use, today, the lack of standardization of drugs and the lack of evidence for future therapeutic solidification does not completely discredit its current role, understanding that more benefits than risks are presented.

DOI:https://doi.org/10.56238/sevened2024.003-051