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Gut-Brain Axis: The role of gut microbiota in immune and neurological homeostasis

Silocchi VM;
Awada SM;
Machado MS;
Silva AV;
Oda JY;
Machado ARSR;
Machado AM

Vinicius Mazoni Silocchi

Samira Mohamad Awada

Mitzy Stephanny Machado

André Valério da Silva

Juliano Yasuo Oda

Aline Rafaela da Silva Rodrigues Machado

Alex Martins Machado


Keywords

Gut-brain
Microbiota
Neurotransmitters
Blood-brain barrier
Enteric nervous system
Neurodegenerative diseases

Abstract

The knowledge of the interaction between the gut microbiota and the central nervous system is growing more and more with surprising discoveries, especially in how it influences aspects of human health. It is worth noting its influence on the regulation of the immune system, based on the production of metabolites. Another important factor in this relationship is the behavior of the blood-brain barrier and the production of neurotransmitters, such as serotonin, which directly impact humoral characteristics and brain function. Not far away, the microbiota is related to the appearance of neurodegenerative and immunological diseases in specific cases. Thus, it is very important to highlight strategies that promote a healthy microbiota with the aim of preventing and treating these conditions, such as therapeutic perspectives with an emphasis on the role of prebiotics and probiotics that act directly in the maintenance of intestinal and brain health.

 

DOI:https://doi.org/10.56238/sevened2024.006-022


Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2024 Vinicius Mazoni Silocchi , Samira Mohamad Awada , Mitzy Stephanny Machado , André Valério da Silva, Juliano Yasuo Oda , Aline Rafaela da Silva Rodrigues Machado , Alex Martins Machado

Author(s)

  • Vinicius Mazoni Silocchi
  • Samira Mohamad Awada
  • Mitzy Stephanny Machado
  • André Valério da Silva
  • Juliano Yasuo Oda
  • Aline Rafaela da Silva Rodrigues Machado
  • Alex Martins Machado